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January 1, 1997Journal of Clinical Oncology

Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients.

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Authors

LSLudi E. SmeelePKPiet J. KostenseIWI. van der Waal

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Overview

Systematic review shows chemotherapy significantly improves overall and disease-free survival in craniofacial osteosarcoma, indicating standard osteosarcoma protocols should be applied.

Key Points

  • To evaluate the impact and potential survival benefit of chemotherapy in patients treated for craniofacial osteosarcoma.
  • Systematic review pooling individual patient data from 20 uncontrolled series published between 1974 and 1994, encompassing 201 patients (mean age 36.6 ± 19.0 years).
  • Documented treatment modalities included surgery (n=180), chemotherapy (n=71), and radiotherapy (n=69).
  • Evaluated overall survival (n=201) and disease-free survival (n=182) using the product-limit method and proportional hazards multiple regression analysis.
  • Chemotherapy significantly improved both overall survival and disease-free survival rates across the entire cohort.
  • Survival advantages from chemotherapy persisted among patients who received complete surgical tumor resection as well as those with incomplete resection.
  • Proportional hazards modeling revealed complete surgical removal and chemotherapy as independent significant prognostic factors, whereas radiotherapy, age, sex, and tumor subsite showed no significant effect.

Cite This Study

Smeele et al. (1997) studied this question.

synapsesocial.com/papers/6a6de1e9febe604dd707d519https://doi.org/10.1200/jco.1997.15.1.363
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