Ni-ZIF-67 derived bimetallic carbon-rich porous polyhedrons for non-enzymatic amperometric glucose sensors

In order to cope with the serious challenge of the global diabetes pandemic, it is urgent to develop a new generation of enzyme-free electrochemical glucose sensors, which are mainly characterized by reliability, sensitivity, high cost-effectiveness, and ease of point-of-care use. In the work, Ni-ZIF-67 and graphite were in-situ mixed to prepare graphite doped Ni-ZIF-67 (Graphite@Ni-ZIF-67), which was employed as sacrificial templates to prepare bimetallic carbon-rich porous polyhedrons (Ni&Co@RCPP). The as-prepared materials were characterized by physical and chemical methods. The results show that Ni&Co@RCPP-4 is multi-element (C, N and Ni) doped spinel-type Co 3 O 4 , and exhibits excellent electrocatalytic activity for direct oxidation of glucose in alkaline medium. The sensors based on Ni&Co@RCPP-4 were evaluated by cyclic voltammetric (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometric (I-t). The as-prepared sensors can detect glucose in a concentration range of 6 - 315 μM with a limit of detection (LOD) of 1.17 µM and an excellent sensitivity of 605.10 μA·mM −1 ·cm −2 , which demonstrates the potential to be applied in point-of-care platforms for noninvasive glucose monitoring.