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This research explores the roles of CD4 regulatory T cells and CD8 Foxp3+ T cells in the immune imbalance of rheumatoid arthritis.

July 3, 2026InflammationOpen Access

Opposing Dynamics of CD4 + Regulatory and CD8 + Foxp3+ T Cells Characterize Immune Imbalance in Rheumatoid Arthritis

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This research explores the roles of CD4 regulatory T cells and CD8 Foxp3+ T cells in the immune imbalance of rheumatoid arthritis.
Enrolled 51 RA patients and 27 healthy controls, grouped by disease activity.
Analyzed clinical data and lymphocyte subsets including CD4 Tregs and CD8 Foxp3+ T cells.
Performed internal validation using bootstrapping and adjusted P-values for false discovery rate.
CD4 Tregs decreased in RA, notably in high disease activity, while CD8 Foxp3+ T increased, particularly in low-to-moderate RA.
The CD4 Treg/CD8 Foxp3+ T ratio effectively distinguished RA from healthy controls.
Combined model with TNF-α and CD4 Treg% achieved a strong AUC of 0.928 for discrimination.

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Randomized trial investigates immune imbalance in rheumatoid arthritis, suggesting new insights into disease management.

Li et al. (2026) studied this question.

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