What question did this study set out to answer?

To evaluate the circulating proportion, immunophenotype, and clinical relevance of CD4+CD25−Foxp3+ T cells in untreated rheumatoid arthritis.

September 6, 2022BMC ImmunologyOpen Access

The proportion and phenotypic changes of CD4+CD25−Foxp3+ T cells in patients with untreated rheumatoid arthritis

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To evaluate the circulating proportion, immunophenotype, and clinical relevance of CD4+CD25−Foxp3+ T cells in untreated rheumatoid arthritis.
Enrolled 61 untreated patients with rheumatoid arthritis and 40 healthy controls.
Quantified CD4+CD25−Foxp3+ T cells, conventional Tregs, phenotypic markers (CTLA4, GITR, Helios, ICOS), and cytokines (IL-17A, IFN-γ, IL-10) using flow cytometry.
Evaluated associations between cell subsets and clinical disease markers (DAS28 score, IgG titer, anti-CCP titer) using Spearman correlation analysis.
Circulating CD4+CD25−Foxp3+ T cells were significantly increased in untreated rheumatoid arthritis compared to healthy controls.
CD4+CD25−Foxp3+ T cells expressed less Helios and produced higher levels of IFN-γ compared to conventional CD4+CD25+Foxp3+ Tregs.
The frequency of CD4+CD25−Foxp3+ T cells correlated positively with RA disease activity, DAS28 scores, IgG titers, and anti-CCP titers.

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Implication

Observational study reveals elevated CD4+CD25−Foxp3+ T cells in untreated rheumatoid arthritis, suggesting a distinct phenotypic role in driving disease activity.

Cite This Study

Ju et al. (2022) studied this question.

synapsesocial.com/papers/6a9bf043c082c33d96f8e9ce https://doi.org/10.1186/s12865-022-00517-0

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Implication

Observational study reveals elevated CD4+CD25−Foxp3+ T cells in untreated rheumatoid arthritis, suggesting a distinct phenotypic role in driving disease activity.

The proportion and phenotypic changes of CD4+CD25−Foxp3+ T cells in patients with untreated rheumatoid arthritis

Key Points

Discussion

Implication

Cite This Study

The proportion and phenotypic changes of CD4+CD25−Foxp3+ T cells in patients with untreated rheumatoid arthritis

Key Points

Discussion

Implication

Cite This Study

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