What question did this study set out to answer?

To examine whether functional CD25brightCD4+ regulatory T cells are present within the inflamed joints of patients with active rheumatoid arthritis.

January 1, 2003European Journal of ImmunologyOpen Access

Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis

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Authors

DCDuojia CaoLund University VMVivianne MalmströmUppsala University CBClare Baecher‐AllanBrigham and Women's Hospital

Discussion

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Implication

Ex vivo analysis demonstrates enrichment of functional CD25brightCD4+ regulatory T cells in rheumatoid arthritis joints, highlighting local immune regulation despite ongoing inflammation.

Key Points

To examine whether functional CD25brightCD4+ regulatory T cells are present within the inflamed joints of patients with active rheumatoid arthritis.
Isolated CD25brightCD4+ T cells from paired synovial fluid and peripheral blood samples of patients with active rheumatoid arthritis.
Assessed regulatory function by measuring in vitro suppression of autologous T-cell proliferation across disease relapses and between symmetrical knee joints.
CD25brightCD4+ T cells were markedly enriched in synovial fluid relative to peripheral blood in patients with active disease.
Synovial CD25brightCD4+ T cells suppressed in vitro proliferation of autologous peripheral blood and synovial fluid T cells, with cell frequencies remaining stable over time during relapses and consistent across bilateral knee joints.

Cite This Study

Cao et al. (2003) studied this question.

synapsesocial.com/papers/6a70a76e26a7f98052dd2209 https://doi.org/10.1002/immu.200390024

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January 1, 2003European Journal of ImmunologyOpen Access

Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis

View Full Paper

Ask AI

Bookmark

Authors

DCDuojia CaoLund University VMVivianne MalmströmUppsala University CBClare Baecher‐AllanBrigham and Women's Hospital

Discussion

Member takes

Implication

Ex vivo analysis demonstrates enrichment of functional CD25brightCD4+ regulatory T cells in rheumatoid arthritis joints, highlighting local immune regulation despite ongoing inflammation.

Key Points

To examine whether functional CD25brightCD4+ regulatory T cells are present within the inflamed joints of patients with active rheumatoid arthritis.
Isolated CD25brightCD4+ T cells from paired synovial fluid and peripheral blood samples of patients with active rheumatoid arthritis.
Assessed regulatory function by measuring in vitro suppression of autologous T-cell proliferation across disease relapses and between symmetrical knee joints.
CD25brightCD4+ T cells were markedly enriched in synovial fluid relative to peripheral blood in patients with active disease.
Synovial CD25brightCD4+ T cells suppressed in vitro proliferation of autologous peripheral blood and synovial fluid T cells, with cell frequencies remaining stable over time during relapses and consistent across bilateral knee joints.

Cite This Study

Cao et al. (2003) studied this question.

synapsesocial.com/papers/6a70a76e26a7f98052dd2209 https://doi.org/10.1002/immu.200390024

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