What question did this study set out to answer?

To investigate the frequency, phenotype, and functional capacity of CD4+CD25+ regulatory T cells in patients with persistent versus extended oligoarticular juvenile idiopathic arthritis.

May 1, 2004The Journal of Immunology

CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

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Authors

IKIsmé M. de KleerSint Franciscus Gasthuis LWLucy R. WedderburnUniversity of London LTLeonie S. TaamsKing's College London

Discussion

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Implication

Comparative analysis reveals elevated regulatory T cells in remitting juvenile idiopathic arthritis, suggesting a protective role against disease progression.

Key Points

To investigate the frequency, phenotype, and functional capacity of CD4+CD25+ regulatory T cells in patients with persistent versus extended oligoarticular juvenile idiopathic arthritis.
Quantified CD4+CD25(bright) and CD4+CD25(int) T cells and measured FoxP3 mRNA expression in paired peripheral blood and synovial fluid samples from patients with persistent and extended oligoarticular juvenile idiopathic arthritis.
Evaluated in vitro suppressive capacity against CD25-negative effector cells and analyzed cell surface maturation markers, including CTLA-4, glucocorticoid-induced TNFR, and HLA-DR.
Patients with persistent oligoarticular JIA displayed significantly higher frequencies of peripheral blood CD4+CD25(bright) T cells and elevated FoxP3 mRNA levels compared with patients with extended disease.
Synovial fluid CD4+CD25(bright) T cells showed increased expression of CTLA-4, glucocorticoid-induced TNFR, and HLA-DR, correlating with enhanced in vitro suppressive capacity relative to peripheral blood counterparts.
Synovial fluid CD4+CD25(int) T cells exhibited significant FoxP3 mRNA expression and in vitro suppressive activity in persistent oligoarticular JIA, leading to higher overall CD4+CD25(total) cell levels than in extended oligoarticular JIA.

Cite This Study

Kleer et al. (2004) studied this question.

synapsesocial.com/papers/6a7fcb662be005d29ebac551 https://doi.org/10.4049/jimmunol.172.10.6435

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Implication

Comparative analysis reveals elevated regulatory T cells in remitting juvenile idiopathic arthritis, suggesting a protective role against disease progression.

CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

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