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To describe cases of paraneoplastic neurological syndromes in ovarian cancer and highlight their clinical implications.

July 3, 2026HealthcareOpen Access

Paraneoplastic Neurological Syndromes in Ovarian Cancer: Case Report and Narrative Review for Diagnostic and Clinical Implications

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To describe cases of paraneoplastic neurological syndromes in ovarian cancer and highlight their clinical implications.
Reported three cases of paraneoplastic neurological syndromes associated with ovarian cancer.
Conducted a narrative review of studies published between 2020 and 2025.
Analyzed timing of onset, clinical presentation, antibody profiles, treatment strategies, and outcomes.
Most neurological symptoms occurred before ovarian cancer diagnosis, indicating early detection potential.
Cerebellar degeneration commonly linked with anti-Yo antibodies; encephalitis often associated with anti-NMDAR antibodies.
Variable outcomes post-treatment, with partial improvement or stabilization in many cases.

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Case reports illustrate paraneoplastic neurological syndromes in ovarian cancer, suggesting early diagnostic potential.

Restaino et al. (2026) studied this question.

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