What question did this study set out to answer?

To characterize the clinical presentation, autoantibody associations, and neurological outcomes of paraneoplastic neurological syndromes (PNS) linked to ovarian neoplasms.

August 14, 2026DiagnosticsOpen Access

Paraneoplastic Neurological Syndromes Associated with Ovarian Tumors: A Case Report and Systematic Review

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To characterize the clinical presentation, autoantibody associations, and neurological outcomes of paraneoplastic neurological syndromes (PNS) linked to ovarian neoplasms.
Conducted a PRISMA-guided systematic review of PubMed and Scopus, identifying 33 eligible studies published between 2016 and 2026.
Documented an illustrative case of a 58-year-old female presenting with anti-Yo-positive cerebellar degeneration (PNS-Care Score: 10/10) and FIGO IIIC high-grade serous ovarian carcinoma.
Anti-NMDAR encephalitis, predominantly associated with benign ovarian teratomas, consistently demonstrated favorable neurological recovery following therapy.
Anti-Yo-associated cerebellar degeneration, primarily linked to epithelial ovarian malignancies, exhibited poor neurological outcomes and progressive disability despite effective tumor reduction and immunotherapy.

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Implication

Systematic review reveals divergent neurological outcomes between anti-Yo degeneration and anti-NMDAR encephalitis in ovarian tumors, highlighting persistent deficits in cancer patients.

Cite This Study

Zahorowska et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec78db70b84ec8b913edb https://doi.org/10.3390/diagnostics16162549

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Implication

Systematic review reveals divergent neurological outcomes between anti-Yo degeneration and anti-NMDAR encephalitis in ovarian tumors, highlighting persistent deficits in cancer patients.

Paraneoplastic Neurological Syndromes Associated with Ovarian Tumors: A Case Report and Systematic Review

Key Points

Discussion

Implication

Cite This Study

Paraneoplastic Neurological Syndromes Associated with Ovarian Tumors: A Case Report and Systematic Review

Key Points

Discussion

Implication

Cite This Study

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