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July 3, 2026Journal of NeurochemistryOpen Access

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

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Authors

KEKristel N. EigenhuisRFRoberto Montoro FerrerRPR. Jeroen Pasterkamp

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Overview

Randomized trial explores ALS mechanisms via hiPSC-derived neural organoids, suggesting new insights into disease pathology.

Key Points

  • To explore disease mechanisms in amyotrophic lateral sclerosis (ALS) using neural organoid models.
  • Utilized three-dimensional human induced pluripotent stem cell (hiPSC)-derived neural organoids.
  • Reviewed various experimental strategies including patient-derived models and pathology induction.
  • Addressed technical challenges in modeling ALS-specific phenotypes.
  • Recapitulated key pathological hallmarks of ALS in neural organoids.
  • Identified structural and molecular abnormalities linking cortical regions to ALS.
  • Discussed insights on cell-type-specific and circuit-level changes related to ALS.

Cite This Study

Eigenhuis et al. (2026) studied this question.

synapsesocial.com/papers/6a47545e5c29257aa2579f2chttps://doi.org/10.1111/jnc.70513
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances and Challenges in the Use of Spinal Cord Organoids in ALS2026
  2. 2Brain Organoids as Emerging Platforms for Modeling Neurodegenerative Diseases: Progress, Challenges, and Future Directions.2026 · 5 citations
  3. 3Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis2024 · 28 citations
  4. 4The Role of Human Pluripotent Stem Cells in Amyotrophic Lateral Sclerosis: From Biological Mechanism to Practical Implications2024 · 5 citations
  5. 5Exploring the Cellular and Molecular Mechanisms Underlying Alzheimer's Disease Utilizing Cerebral Organoids Derived from Patient-specific Induced Pluripotent Stem Cells (iPSCs): A Review with Implications for Surgical Interventions2026