Key result
Early administration of ghrelin significantly reduced mortality (23% vs 61% in untreated controls) and prevented the increase in cardiac sympathetic nerve activity in rats with acute MI.
Why the study?
Does early ghrelin administration prevent an increase in cardiac sympathetic nerve activity and reduce mortality in rats with acute myocardial infarction?
Does early ghrelin administration prevent an increase in cardiac sympathetic nerve activity and reduce mortality in rats with acute myocardial infarction?
Absolute Event Rate: 23% vs 61%
Early ghrelin treatment in a rat model of acute myocardial infarction prevents the acute increase in cardiac sympathetic tone and significantly reduces short-term mortality.
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Ghrelin prevents post-MI CSNA rise and improves survival in rats; leaves open translation to human acute MI trials.
Schwenke et al. (2008) studied Acute myocardial infarction. Ghrelin vs. Saline was evaluated on Mortality. Early administration of ghrelin significantly reduced mortality (23% vs 61% in untreated controls) and prevented the increase in cardiac sympathetic nerve activity in rats with acute MI.
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