Key result
In rats with myocardial infarction, ghrelin administration attenuated left ventricular enlargement and decreased the low-to-high frequency ratio of heart rate variability (P<0.01).
Why the study?
Does ghrelin attenuate left ventricular remodeling and suppress cardiac sympathetic activity in rats with myocardial infarction?
Population
Sprague-Dawley rats with myocardial infarction
Comparison
Ghrelin 100 microg/kg subcutaneous twice daily… vs Saline
Design
Preclinical
Follow-up
2 weeks
Authors
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Does not support clinical ghrelin use post-MI; extends preclinical evidence on sympathetic modulation of remodeling.
Does ghrelin attenuate left ventricular remodeling and suppress cardiac sympathetic activity in rats with myocardial infarction?
p-value: p=<0.01
Ghrelin administration attenuates early left ventricular remodeling and suppresses cardiac sympathetic activity in a rat model of myocardial infarction, suggesting potential as a cardioprotective hormone.
Soeki et al. (2007) studied Myocardial infarction (n=36). Ghrelin vs. Saline was evaluated on Left ventricular remodeling and autonomic nervous function (p=<0.01). In rats with myocardial infarction, ghrelin administration attenuated left ventricular enlargement and decreased the low-to-high frequency ratio of heart rate variability (P<0.01).
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