Key result
Severe resting gradient and basal hypertrophy in oHCM linked to ~98% higher mortality after ASA.
Why the study?
To investigate the short- and long-term efficiency of alcohol septal ablation across obstructive hypertrophic cardiomyopathy patient groups defined by baseline resting LVOT gradient and basal septal hypertrophy severity.
Does baseline LVOT gradient and basal septal hypertrophy severity affect long-term survival and reoperation rates after alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy?
Population
212 oHCM patients undergoing alcohol septal ablation
Comparison
Outcomes across 4 groups stratified by resting LVOT gradient (<50 vs ≥50 mmHg) and basal hypertrophy (<20 vs ≥20 mm)
Design
Cohort study
Follow-up
Median 74 (38–127) months
Authors
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In patients with obstructive hypertrophic cardiomyopathy undergoing alcohol septal ablation, the presence of both severe resting LVOT gradient and severe basal hypertrophy at baseline is associated with higher long-term mortality and reintervention rates.
Cohort (n=212)
Yes
Does baseline LVOT gradient and basal septal hypertrophy severity affect long-term survival and reoperation rates after alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy?
Hazard Ratio: 1.98 (95% CI 1.06–3.72)
p-value: p=0.029
In patients with obstructive hypertrophic cardiomyopathy undergoing alcohol septal ablation, the presence of both severe resting LVOT gradient and severe basal hypertrophy at baseline is associated with higher long-term mortality and reintervention rates.
Kashtanov et al. (2024) conducted a cohort in Obstructive hypertrophic cardiomyopathy (n=212). Severe LVOT gradient (≥50 mmHg) and severe basal hypertrophy (≥20 mm) at baseline vs. Non-severe LVOT gradient (<50 mmHg) and/or non-severe basal hypertrophy (<20 mm) at baseline was evaluated on Long-term mortality (HR 1.98, 95% CI 1.06-3.72, p=0.029). Patients with obstructive hypertrophic cardiomyopathy who had a severe resting gradient (≥50 mmHg) and severe basal hypertrophy (≥20 mm) at baseline had a significantly higher risk of long-term mortality after alcohol septal ablation compared to those without both severe features (HR 1.98).
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