Key result
Mitral valve plasty significantly reduced death, MV dysfunction, reoperation, and thromboembolic events compared to replacement in adults with HOCM and MR (HR 0.68; 95% CI 0.57-0.82; P=0.002).
Why the study?
Does mitral valve plasty compared to mitral valve replacement reduce the composite of death, postoperative MV dysfunction, reoperation rates, and thromboembolic events in adult patients with hypertrophic obstructive cardiomyopathy and mitral regurgitation?
Population
Adult patients with hypertrophic obstructive cardiomyopathy and systolic anterior motion of the anterior…
Comparison
Mitral valve plasty (MVP) / repair vs Mitral valve replacement (MVR)
Design
Meta-analysis
Authors
Loading...
MVP favored over MVR to reduce DFRE in HOCM with MR; supports repair-first surgical strategy in this population.
Meta-Analysis
Does mitral valve plasty compared to mitral valve replacement reduce the composite of death, postoperative MV dysfunction, reoperation rates, and thromboembolic events in adult patients with hypertrophic obstructive cardiomyopathy and mitral regurgitation?
Hazard Ratio: 0.68 (95% CI 0.57–0.82)
p-value: p=0.002
In adult patients with hypertrophic obstructive cardiomyopathy and mitral regurgitation, mitral valve repair is superior to replacement for preventing death, valve dysfunction, reoperation, and thromboembolic events.
Afanasyev et al. (2018) conducted a meta-analysis in Hypertrophic obstructive cardiomyopathy and systolic anterior motion of the anterior mitral leaflet-mediated MV regurgitation (HOCM & MR). Mitral valve plasty (MVP) vs. Mitral valve replacement (MVR) was evaluated on Death, postoperative MV dysfunction, reoperation rates and thromboembolic events (DFRE) (HR 0.68, 95% CI 0.57-0.82, p=0.002). Mitral valve plasty significantly reduced death, MV dysfunction, reoperation, and thromboembolic events compared to replacement in adults with HOCM and MR (HR 0.68; 95% CI 0.57-0.82; P=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: