What question did this study set out to answer?

This research aims to explore the nickel-catalyzed intramolecular decarbonylative coupling of thioesters and elucidate the underlying mechanisms involved in this transformation.

July 4, 2026Journal of CatalysisOpen Access

Nickel-catalyzed intramolecular decarbonylative coupling of thioesters: from optimization to mechanistic insights into precatalyst activation and Ni(0) reactivity

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This research aims to explore the nickel-catalyzed intramolecular decarbonylative coupling of thioesters and elucidate the underlying mechanisms involved in this transformation.
Nickel complexes supported by dppa-type ligands were used as precatalysts.
In situ generation of catalytically active nickel(0) species was demonstrated.
Mechanistic insights were gained using catalytic studies, stoichiometric experiments, and in situ 31P{1H} NMR monitoring.
Oxidative addition of thioester and decarbonylation occurred readily at room temperature.
Reductive elimination required elevated temperatures, indicating a stepwise mechanism.
Nickel(0) carbonyl complexes were observed and proposed to be in equilibrium with active nickel(0) species, influenced by carbon monoxide.

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Implication

Randomized trial investigates nickel-catalyzed transformation of thioesters, suggesting novel mechanistic insights.

Cite This Study

Fagué et al. (2026) studied this question.

synapsesocial.com/papers/6a48a30989561a0c2d78d4e8 https://doi.org/10.1016/j.jcat.2026.117043

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Nickel-catalyzed intramolecular decarbonylative coupling of thioesters: from optimization to mechanistic insights into precatalyst activation and Ni(0) reactivity

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Discussion

Implication

Cite This Study

Nickel-catalyzed intramolecular decarbonylative coupling of thioesters: from optimization to mechanistic insights into precatalyst activation and Ni(0) reactivity

Key Points

Discussion

Implication

Cite This Study

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