What question did this study set out to answer?

The aim is to improve nickel catalysts by creating air-stable Ni(0) precatalysts for more efficient cross-coupling reactions.

February 8, 2026Open Access

Recent Developments in the Field of Air‐Stable Nickel(0) Precatalysts for Cross‐Coupling Reactions

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This research develops air-stable nickel(0) precatalysts, enhancing cross-coupling reactions and enabling efficient synthesis.

The aim is to improve nickel catalysts by creating air-stable Ni(0) precatalysts for more efficient cross-coupling reactions.
Developed bench-stable Ni(0) complexes to enhance handling and usability.
Utilized ligand exchange from air-sensitive [Ni(COD)$_2$] and reduction of Ni(II) salts.
Designed targeted ligands with strong π-acceptors and donors.
Successfully created Ni(0) precatalysts that are stable in air and moisture.
Demonstrated improved catalytic activity for C–C and C–heteroatom cross-coupling reactions.
Enabled compatibility with high-throughput discovery methods.

Flecken et al. (2026) studied this question.

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