What question did this study set out to answer?

To synthesize and evaluate solution-stable nickel(0) precatalysts supported by diazabutadiene and alkene ligands for high-throughput cross-coupling reactions.

January 16, 2025Chemistry - A European JournalOpen Access

Easily Accessible and Solution‐Stable Ni(0) Precatalysts for High‐Throughput Experimentation

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To synthesize and evaluate solution-stable nickel(0) precatalysts supported by diazabutadiene and alkene ligands for high-throughput cross-coupling reactions.
Synthesized and characterized N,N'-diaryl diazabutadiene (DAB) Ni(0) complexes bearing stabilizing alkene ligands.
Assessed complex solubility and stability across multiple organic solvents for in situ activation.
Conducted high-throughput experimentation (HTE) to benchmark catalytic performance against bis(1,5-cyclooctadiene)nickel(0) [Ni(COD)2] in Suzuki and C–N coupling transformations.
Synthesized DAB-Ni(0) complexes demonstrated robust solubility and persistence in several standard organic solvents.
High-throughput catalytic screening revealed the precatalysts achieved equal or superior yields relative to the standard Ni(COD)2 precatalyst in both Suzuki and C–N bond-forming reactions.

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Implication

Experimental study demonstrates solution-stable Ni(0) diazabutadiene complexes match or outperform Ni(COD)2 in cross-coupling reactions, suggesting broader utility for high-throughput screening.

Cite This Study

Thomas et al. (2025) studied this question.

synapsesocial.com/papers/6a83415a65d10cbb45d9cb62 https://doi.org/10.1002/chem.202403960

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Implication

Experimental study demonstrates solution-stable Ni(0) diazabutadiene complexes match or outperform Ni(COD)2 in cross-coupling reactions, suggesting broader utility for high-throughput screening.

Easily Accessible and Solution‐Stable Ni(0) Precatalysts for High‐Throughput Experimentation

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Implication

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Easily Accessible and Solution‐Stable Ni(0) Precatalysts for High‐Throughput Experimentation

Key Points

Discussion

Implication

Cite This Study

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