Key result
Infective endocarditis shifts to S. aureus, with higher mortality in prosthetic valve and device patients.
Why the study?
Infective endocarditis carries substantial mortality risk, with epidemiology shifting toward Staphylococcus aureus, and management is complicated by prosthetic valves or intracardiac devices.
This scoping review highlights the shifting epidemiology of infective endocarditis toward Staphylococcus aureus and emphasizes the complexities of managing infections involving prosthetic valves or intracardiac devices.
Answers are grounded in this paper and cite their sources.
Supports heightened S. aureus suspicion in IE; leaves open optimal management of prosthetic/device infections.
Infective endocarditis continues to carry substantial mortality risk, with its epidemiology shifting from viridans streptococci as the most common cause to Staphylococcus aureus as the predominant pathogen, in part driven by increasing intravenous drug use and healthcare-associated infections. Optimal treatment depends on targeted antimicrobial therapy guided by blood culture results and susceptibility data. Management is further complicated in patients with prosthetic valves or intracardiac devices, as these infections are linked to higher mortality, more frequent complications, and increased rates of treatment failure.
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Bogni et al. (2026) conducted a review in Infective endocarditis. Management of Infective Endocarditis was evaluated. Infective endocarditis epidemiology has shifted to Staphylococcus aureus, with higher mortality and treatment failure rates observed in patients with prosthetic valves or intracardiac devices.
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