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July 4, 2026BMC Cardiovascular DisordersOpen Access

Novel TyG index nomogram strongly predicts MACE in post-PCI STEMI patients with a 0.80 C-index.

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Why the study?

This study aimed to develop and validate a nomogram utilizing the TyG index alongside readily available clinical data to predict the prognosis of STEMI patients undergoing primary PCI.

Can a nomogram incorporating the TyG index accurately predict MACE risk in STEMI patients undergoing primary PCI?

Population

1022 STEMI patients undergoing primary PCI (training n = 715, validation n = 307)

Design

Retrospective cohort study

Key result

A novel nomogram integrating the TyG index with clinical markers demonstrated strong discrimination for predicting MACE in STEMI patients after primary PCI (validation C-index 0.80; 95% CI 0.76-0.83).

Authors

JHJinyong HuangJZJunyi ZhangLLLi Li

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Overview

May support MACE risk stratification in STEMI post-PCI; leaves open clinical adoption pending prospective validation.

Key Points

  • This research aims to create and validate a nomogram to predict outcomes for STEMI patients undergoing primary PCI using the triglyceride-glucose index and clinical data.
  • Analyzed data from 1022 STEMI patients, divided into training (n=715) and validation cohorts (n=307).
  • Developed a predictive nomogram using LASSO-penalized Cox regression with five key predictors.
  • Evaluated model performance via ROC curve analysis, calibration plots, Harrell’s C-index, and decision curve analysis.
  • Harrell’s C-index was 0.73 (95% CI: 0.70–0.75) for training and 0.80 (95% CI: 0.76–0.83) for validation, indicating strong discrimination.
  • AUC for 1-year and 2-year MACE predictions was 0.77 in the training cohort and 0.86 in the validation cohort, demonstrating excellent accuracy.
  • Subgroup analysis showed AUC values from 0.74 to 0.87 across different age groups, confirming model robustness.

Study Design

Type

Cohort (n=1,022)

Structured PICO

Can a nomogram incorporating the TyG index accurately predict MACE risk in STEMI patients undergoing primary PCI?

P
Population
1,022 patients with STEMI undergoing primary PCI, analyzed retrospectively to develop and validate a TyG index-based predictive nomogram for 1- and 2-year MACE.
E
Exposure
Predictive nomogram incorporating residual SYNTAX score (rSS), number of affected coronary vessels (VDn), high-sensitivity C-reactive protein (hsCRP), triglyceride-glucose (TyG) index, and B-type natriuretic peptide (BNP)
O
Outcome
1-year and 2-year major adverse cardiovascular events (MACE)composite

Main Result

Effect estimate: C-index 0.80 (95% CI 0.76-0.83)

A novel nomogram incorporating the TyG index, hsCRP, rSS, VDn, and BNP provides accurate risk stratification for MACE in STEMI patients following primary PCI.

Cite This Study

Huang et al. (2026) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=1,022). Triglyceride-glucose (TyG) index-based nomogram was evaluated on Model discrimination for major adverse cardiovascular events (MACE) (C-index 0.80, 95% CI 0.76-0.83). A novel nomogram integrating the TyG index with clinical markers demonstrated strong discrimination for predicting MACE in STEMI patients after primary PCI (validation C-index 0.80; 95% CI 0.76-0.83).

synapsesocial.com/papers/6a48a47889561a0c2d78dc9chttps://doi.org/10.1186/s12872-026-06156-2
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