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July 4, 2026Biomicrofluidics

Navigating melanoma heterogeneity: Advanced microfluidic CTC capture strategies and AI-assisted immunotherapy response prediction

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Authors

JPJunjun PuJLJilin LiXSXinxiang Su

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Overview

Review explores advanced microfluidic techniques to enhance liquid biopsy efficacy in melanoma, indicating potential for improved immunotherapy outcomes.

Key Points

  • This review examines the challenges of melanoma heterogeneity and the potential of advanced capture strategies to inform immunotherapy response.
  • Analyzed the limitations of traditional tissue biopsies in capturing clonal evolution.
  • Evaluated advanced microfluidic techniques for label-free capture of circulating tumor cells.
  • Explored AI-assisted models for monitoring immunotherapy responses.
  • Advanced microfluidic strategies effectively capture aggressive MES clones, reducing false-negative rates compared to conventional methods.
  • Single-cell omics provide critical insights into resistance mechanisms in melanoma treatments.
  • AI-driven models facilitate navigation through the complexities of personalized immunotherapy.

Cite This Study

Pu et al. (2026) studied this question.

synapsesocial.com/papers/6a48a4c689561a0c2d78debbhttps://doi.org/10.1063/5.0324164
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