17P Single-cell profiling guides a disease-tailored TCR-based immunotherapy for epithelial ovarian cancer

M.C.C. Maffia; A. Simioni; E. Tassi; A. Bergamini; C. Balestrieri; Z. Magnani; B. Camisa; D. Abbati; L. Perani; G. Candotti; L. Bocciolone; G. Pavone; M Candiani; M. Sant' Angelo; C. Doglioni; F. Sanvito; B. Shultes; A. Prodeus; E. Ruggiero; C. Bonini

doi:10.1016/j.esmoop.2026.108042

Key Points

The aim is to understand how specific inhibitory receptors affect T-cell dysfunction and their role in enhancing immunotherapy for epithelial ovarian cancer.
Utilized single-cell profiling to analyze T-cell populations in the tumor microenvironment.
Assessed the influence of inhibitory receptors on T-cell activity.
Examined the potential for tailored TCR-based immunotherapy based on findings.
Identified key inhibitory receptors associated with T-cell dysfunction.
Demonstrated potential therapeutic pathways for improving T-cell function.
Showed that tailored TCR-based immunotherapy could effectively redirect T-cell responses.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Evaluates TCR-based immunotherapy impact on T-cell function in epithelial ovarian cancer, suggesting a new approach to treatment.

Abstract

Epithelial ovarian cancer (EOC) is characterized by a profoundly immunosuppressive tumor microenvironment. Although T-cell infiltration is a key prognostic factor, the hierarchical contribution of specific inhibitory receptors (IRs) to T-cell dysfunction—and their relative impact on therapeutic redirection—remains unclear.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Maffia et al. (2026) studied this question.

synapsesocial.com/papers/6a48a60a89561a0c2d78e538 https://doi.org/10.1016/j.esmoop.2026.108042

View Full Paper

Ask AI

Bookmark

Share

17P Single-cell profiling guides a disease-tailored TCR-based immunotherapy for epithelial ovarian cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

17P Single-cell profiling guides a disease-tailored TCR-based immunotherapy for epithelial ovarian cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading