Pathobiology and Interactions of the MiTF Signaling Pathways

MiT/TFE family of transcription factors, including MiTF, TFE3, TFEB, and TFEC genes, control transcriptional programs for autophagy and lysosome biogenesis and regulate energy metabolism in many cancers. Chromosomal translocations and amplifications involving the MiT/TFE genes contribute to the etiology and pathophysiology of renal cell carcinoma, melanoma, sarcomas, and many other tumors. Understanding the roles of MiT/TFE factors in cellular homeostasis, oncogenic, and stress-adaptive regulation through transcriptionally regulated pathways may reveal new strategies for cancer diagnostics, prognostication, and treatment.