Key result
Maternal intravenous magnesium controlled fetal ventricular tachycardia secondary to long QT syndrome within 12 hours, though the infant ultimately died after preterm delivery.
Why the study?
Does maternal intravenous magnesium control fetal ventricular tachycardia secondary to long QT syndrome?
Case Report (n=1)
Does maternal intravenous magnesium control fetal ventricular tachycardia secondary to long QT syndrome?
Maternal intravenous magnesium can rapidly control fetal ventricular tachycardia secondary to long QT syndrome, though severe neurological complications and death may still occur due to prior hydrops or hypoperfusion.
Maternal IV magnesium may control fetal VT in long QT syndrome; leaves open effect on survival after preterm delivery.
Ventricular tachycardia is a very rare fetal arrhythmia accounting for fewer than 2% of fetal tachycardias. We describe a fetus presenting at 30 weeks' gestation with ventricular tachycardia at a rate of 220 beats per min and fetal hydrops. The tachycardia was unresponsive to flecainide but was controlled within 12 h by an intravenous infusion of magnesium to the mother. Despite rapid control of the arrhythmia the fetus developed severe periventricular leukomalacia before birth for which a poor neurological prognosis was given. The baby was delivered preterm at 32 weeks' gestation and died on the sixth day after birth. Long QT syndrome was identified postnatally on the electrocardiogram, and was confirmed by genetic testing which showed a mutation in the KCNH2 gene (p.T613M).
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Simpson et al. (2009) conducted a case report in Fetal ventricular tachycardia secondary to long QT syndrome (n=1). Maternal intravenous magnesium was evaluated on Control of fetal ventricular tachycardia. Maternal intravenous magnesium controlled fetal ventricular tachycardia secondary to long QT syndrome within 12 hours, though the infant ultimately died after preterm delivery.
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