Key result
Intracoronary adenosine increased total coronary blood volume by 75%, coronary blood flow by 574%, and myocardial oxygen tension by 122%, but did not significantly affect small-vessel blood volume.
Intracoronary adenosine causes relaxation of arteriolar resistance vessels and larger vessels, but not precapillary sphincters, likely due to the opposing action of increased myocardial oxygen tension.
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Adenosine's effects in dogs should not inform clinical coronary interventions; leaves open vessel-specific mechanisms for human validation.
Crystal et al. (1981) studied this question. intracoronary adenosine was evaluated on total (CBV) and small-vessel blood volume (MSVBV), hematocrit (MSVHct), and related parameters of O2 supply-demand ratio. Intracoronary adenosine increased total coronary blood volume by 75%, coronary blood flow by 574%, and myocardial oxygen tension by 122%, but did not significantly affect small-vessel blood volume.
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