Key result
Intracoronary adenosine increased total coronary blood volume by 75%, coronary blood flow by 574%, and myocardial oxygen tension by 122%, but did not significantly affect small-vessel blood volume.
Population
Anesthetized open-chest dogs (left ventricular myocardium)
Design
Preclinical
Authors
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Adenosine's effects in dogs should not inform clinical coronary interventions; leaves open vessel-specific mechanisms for human validation.
Intracoronary adenosine causes relaxation of arteriolar resistance vessels and larger vessels, but not precapillary sphincters, likely due to the opposing action of increased myocardial oxygen tension.
Crystal et al. (1981) studied this question. intracoronary adenosine was evaluated on total (CBV) and small-vessel blood volume (MSVBV), hematocrit (MSVHct), and related parameters of O2 supply-demand ratio. Intracoronary adenosine increased total coronary blood volume by 75%, coronary blood flow by 574%, and myocardial oxygen tension by 122%, but did not significantly affect small-vessel blood volume.
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