Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71

Huang et al. (2014) conducted an observational in Enterovirus 71 infection (n=188). Non-synonymous mutations in non-structural protein regions vs. Structural protein regions was evaluated on Phylogenetic evolution and amino acid substitutions. Non-synonymous mutations predominantly in the non-structural protein coding region contribute to the intra-genotypic evolution and re-emergence of enterovirus 71 genotypes.