Key result
Enterovirus 71 3C protein mediates the cleavage of IRF7 at the Q189-S190 junction, inhibiting its ability to activate interferon expression and allowing the virus to escape cellular responses.
Population
Mammalian cells
Comparison
Enterovirus 71 (EV71) 3C protein expression vs Mutant 3C proteins (H40D, R84Q, V154S) or control
Design
Preclinical
Authors
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Should not alter EV71 management; leaves open whether 3C-IRF7 cleavage is targetable in human disease.
EV71 uses its 3C protein to cleave IRF7, thereby suppressing the host type I interferon response and promoting viral replication.
Lei et al. (2012) studied Enterovirus 71 infection. Enterovirus 71 3C protein was evaluated on Cleavage of IRF7 and activation of IFN expression. Enterovirus 71 3C protein mediates the cleavage of IRF7 at the Q189-S190 junction, inhibiting its ability to activate interferon expression and allowing the virus to escape cellular responses.
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