Key result
Total and afferent-selective renal sympathetic denervation attenuated DOCA-salt induced hypertension in rats (111±8 and 117±5 mm Hg, respectively, vs 132±12 mm Hg in Sham).
Why the study?
Does afferent-selective or total renal sympathetic denervation attenuate hypertension and renal inflammation in a DOCA-salt rat model?
Population
Uninephrectomized male Sprague-Dawley rats treated with 100-mg deoxycorticosterone acetate subcutaneously…
Comparison
Afferent-selective renal sympathetic denervation… vs Sham procedure (n=10)
Design
Preclinical
Follow-up
21 days
Authors
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Afferent-selective RDNx may lower BP without anti-inflammatory effects in this model; leaves open clinical translation of selective denervation.
Does afferent-selective or total renal sympathetic denervation attenuate hypertension and renal inflammation in a DOCA-salt rat model?
Absolute Event Rate: 111% vs 132%
In a DOCA-salt rat model, afferent renal nerve activity appears to mediate the hypertensive response, while renal inflammation is primarily driven by efferent renal sympathetic nerve activity.
Banek et al. (2016) studied Hypertension (n=30). Total or afferent-selective renal sympathetic denervation (RDNx) vs. Sham was evaluated on Mean arterial pressure. Total and afferent-selective renal sympathetic denervation attenuated DOCA-salt induced hypertension in rats (111±8 and 117±5 mm Hg, respectively, vs 132±12 mm Hg in Sham).
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