Key result
Empirical left atrial appendage isolation using a second-generation cryoballoon resulted in left atrial appendage thrombus formation in 1 patient in less than 24 hours.
Case Report (n=1)
Empirical LAA isolation using a second-generation cryoballoon can lead to rapid LAA thrombus formation within 24 hours, highlighting the need for post-procedural screening or LAA closure.
Alerts to LAA thrombus risk after CB2 LAAI; leaves open comparative safety data versus RF.
Key Teaching Points•Empirical electrical isolation of the left atrial appendage (LAAI) using radiofrequency (RF) current in addition to pulmonary vein isolation has been shown to increase clinical success. Although potentially effective, this strategy may be associated with an increased risk for left atrial appendage (LAA) thrombus formation and subsequent thromboembolic events.•LAA thrombus formation is possible after empirical LAAI using a second-generation cryoballoon (CB2).•Although we report the case of a single patient, our finding highlights the importance of screening patients for LAA thrombi after RF- or CB2-based LAAI.•LAA closure seems to be a reasonable strategy to prevent LAA thrombus formation after LAAI. •Empirical electrical isolation of the left atrial appendage (LAAI) using radiofrequency (RF) current in addition to pulmonary vein isolation has been shown to increase clinical success. Although potentially effective, this strategy may be associated with an increased risk for left atrial appendage (LAA) thrombus formation and subsequent thromboembolic events.•LAA thrombus formation is possible after empirical LAAI using a second-generation cryoballoon (CB2).•Although we report the case of a single patient, our finding highlights the importance of screening patients for LAA thrombi after RF- or CB2-based LAAI.•LAA closure seems to be a reasonable strategy to prevent LAA thrombus formation after LAAI.
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Tilz et al. (2018) conducted a case report in Left atrial appendage thrombus (n=1). Empirical cryoballoon-based left atrial appendage isolation (CB2) was evaluated on Left atrial appendage thrombus formation. Empirical left atrial appendage isolation using a second-generation cryoballoon resulted in left atrial appendage thrombus formation in 1 patient in less than 24 hours.
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