Key result
Injectable hydrogels show promise for MI therapy by providing mechanical support and promoting angiogenesis.
Why the study?
Current therapeutic approaches for myocardial infarction have inherent limitations, highlighting the need to explore emerging injectable hydrogels that provide biocompatibility, injectability, and mechanical support for myocardial tissue repair.
This review highlights the potential of multifunctional injectable hydrogels as an emerging therapeutic strategy for myocardial repair and regeneration post-myocardial infarction.
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Injectable hydrogels warrant clinical trial evaluation for post-MI repair; extends preclinical biomaterial concepts toward translation.
Myocardial infarction (MI) remains the leading cause of death in patients with cardiovascular disease worldwide, with therapeutic approaches predominantly relying on medication, medical device implantation, and organ transplantation, each constrained by inherent limitations. Injectable hydrogels have recently emerged as promising therapeutic tools, noted for their biocompatibility, injectability, and capacity to provide mechanical support crucial for myocardial tissue repair. This review aims to comprehensively explore the interaction between injectable hydrogels and myocardial repair post‐infarction. It encompasses recent advancements in various types of injectable hydrogels used in MI therapy, including those modulating microenvironments, conducting electricity, influencing immunomodulation, promoting angiogenesis, and improving ischemia‐reperfusion conditions. By synthesizing current research findings, this review facilitates interdisciplinary knowledge integration and the development of effective prognostic indicators for injectable materials.
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Lu et al. (2024) conducted a review in Myocardial infarction. Injectable hydrogels was evaluated. Injectable hydrogels offer a promising therapeutic approach for myocardial infarction by providing mechanical support, modulating microenvironments, and promoting angiogenesis and tissue repair.
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