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November 18, 2025Discover MaterialsOpen Access

Recent advances in biomimetic hydrogel materials for cardiac medicine applications

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Key result

Biomimetic hydrogels, including injectable formulations and cardiac patches, offer a promising therapeutic approach for myocardial infarction by providing mechanical support and promoting cardiac tissue regeneration.

Why the study?

The scarcity of donor hearts for myocardial infarction treatment highlights the need for alternative therapies such as biomimetic hydrogels for cardiac repair.

Design

Review

Authors

SSSumbul SaeedSKShahid Ullah KhanAKAbdul Jamil Khan

Discussion

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Overview

Should not yet change post-MI care; leaves open whether biomimetic hydrogels will translate from early-stage promise to proven clinical benefit.

Structured PICO

P
Population
Patients and preclinical models with myocardial infarction (MI) and subsequent heart failure
I
Intervention
Biomimetic hydrogel materials, including natural, synthetic, and hybrid injectable hydrogels and cardiac patches

Biomimetic hydrogels represent a promising therapeutic approach for cardiac tissue regeneration and repair following myocardial infarction, though most applications remain in early clinical or preclinical stages.

Limitations

  • Natural hydrogels can exhibit weak mechanical qualities, a high degree of batch variability, and immunogenicity.
  • Synthetic thermo-gelators may be non-biodegradable, potentially causing long-term inflammation.
  • Biodegradable formulations can suffer from mechanical weakening during degradation, and gelation kinetics are challenging to control.
  • pH-sensitive hydrogels face challenges with premature degradation, generation of harmful byproducts, and the need for precise polymer tuning.
  • Most hydrogel technologies are still in preclinical stages
  • Natural hydrogels can exhibit weak mechanical qualities, batch variability, and immunogenicity
  • Synthetic thermo-responsive hydrogels may be non-biodegradable and cause long-term inflammation

Cite This Study

Saeed et al. (2025) conducted a review in Myocardial infarction. Biomimetic hydrogels was evaluated. Biomimetic hydrogels, including injectable formulations and cardiac patches, offer a promising therapeutic approach for myocardial infarction by providing mechanical support and promoting cardiac tissue regeneration.

synapsesocial.com/papers/6a7f0b08084666b5350d396chttps://doi.org/10.1007/s43939-025-00440-2
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Injectable Conductive Hydrogel Containing Black Phosphorus Nanosheets Inhibits the Oxidative Stress-Inflammation Chain during Myocardial Infarction2023 · 20 citations
  2. 2Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications2022 · 227 citations