Hydrogel microneedles offer a promising approach for myocardial infarction treatment by enabling minimally invasive delivery, controlled release of therapeutic agents, and electrical signal restoration.
Hydrogel microneedles represent a promising, minimally invasive technology for targeted therapy and cardiac repair following myocardial infarction.
Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, often progressing to heart failure due to inadequate tissue repair and adverse remodeling. Conventional therapeutic strategies, including pharmacological interventions and surgical procedures, exhibit limited efficacy in restoring cardiac function, highlighting the urgent need for innovative approaches. Hydrogel microneedles (MNs) have recently emerged as a groundbreaking technology for MI treatment, combining the advantages of minimally invasive delivery, targeted therapy, and multifunctional integration. Furthermore, the integration of therapeutic agents into hydrogel MNs enable sequentially controlled release within the infarcted myocardium, addressing key pathological processes such as oxidative stress, inflammation, and fibrosis. Additionally, the incorporation of conductive components into hydrogel MNs facilitate the restoration of electrical signal propagation, promoting synchronized cardiomyocyte contraction and mitigating arrhythmic. This article briefly surveys the latest advancements in hydrogel MN for cardiac repair. Key issues and challenges, as well as recommendations for future research, are also discussed.
Li et al. (Wed,) conducted a review in Myocardial infarction. Hydrogel microneedles was evaluated. Hydrogel microneedles offer a promising approach for myocardial infarction treatment by enabling minimally invasive delivery, controlled release of therapeutic agents, and electrical signal restoration.