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Discusses the underutilization of FFR in intermediate coronary lesions and the potential of AI-derived coronary physiology to overcome current obstacles.
Physiology-guided percutaneous coronary intervention using fractional flow reserve (FFR) is currently the recommended standard for decision-making in intermediate coronary lesions1,2; however, real-world data suggest that FFR remains seriously underutilized for this purpose, with estimates of its use ranging from 15% to 30% of possible cases.3-5 Obstacles to the widespread adoption of FFR to assess intermediate lesions beyond their angiographic aspects are the time, expense, and potential risk involved in intracoronary pressure-wire manipulation and the medications used to achieve maximal hyperemia.
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Fang et al. (2026) conducted an editorial in Intermediate coronary lesions. Fractional flow reserve (FFR) was evaluated.
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