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July 5, 2026ACS Applied Polymer Materials

Rapidly Photocured Catechol-Thiol Adhesive for Wet and Submerged Biological Interfaces

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Authors

JBJacob BoykinFlorida A&M University - Florida State University College of EngineeringBSBiswajit SahaIndian Institute of Science Education and Research KolkataMTMathew ThomasMayo Clinic

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Implication

Randomized trial demonstrates strong adhesion in wet environments, suggesting a new solution for tissue sealing.

Key Points

  • This research aims to create a safe and effective adhesive for internal tissue sealing that overcomes limitations of existing products.
  • Developed a photocurable adhesive using catechol monomers and multifunctional thiols.
  • Measured adhesion strengths on various substrates under wet and dry conditions.
  • Evaluated cytocompatibility using flow cytometry analysis over 72 hours.
  • Achieved dry adhesion strength of 164 kPa, comparable to cyanoacrylate.
  • Maintained adhesion strength of 144 kPa on wet porcine skin-polypropylene interfaces.
  • Demonstrated over 96% cell viability, indicating excellent cytocompatibility.

Cite This Study

Boykin et al. (2026) studied this question.

synapsesocial.com/papers/6a49f411f5d1d45b287ffc64https://doi.org/10.1021/acsapm.6c01045
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