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July 5, 2026BiomoleculesOpen Access

HDAC3 as an Immunometabolic Rheostat: Molecular Mechanisms of Deacylation Plasticity, Lactylation Dynamics, and Spatiotemporal Regulation

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Authors

YBYifan BuWLWanying LiSLSongzhe Li

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Overview

Review examines HDAC3's role in regulating inflammatory responses and metabolic processes, suggesting new treatment strategies.

Key Points

  • This review aims to explore the multifaceted role of HDAC3 in linking immunometabolism and chromatin regulation.
  • Review of current literature on HDAC3 activity and regulatory mechanisms.
  • Analysis of lysine lactylation and delactylase activities in biochemical systems.
  • Discussion on the spatial regulation of HDAC3 in inflammatory and metabolic contexts.
  • Confirmed HDAC3 functions beyond traditional deacetylation to include delactylase activity.
  • Identified lactate load influences the catalytic output of HDAC3 on various substrates.
  • Proposed HDAC3 plays a role in inflammatory homeostasis and metabolic stress management.

Cite This Study

Bu et al. (2026) studied this question.

synapsesocial.com/papers/6a49f4b8f5d1d45b287fffe2https://doi.org/10.3390/biom16070980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophage HDAC3 drives obesity and adipose tissue metabolic maladaptation through GDF3-mediated inflammation and chromatin remodeling2026
  2. 2Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes2024 · 16 citations
  3. 3HDAC3 prevents enhancer hyperactivation to enable developmental transitions2025
  4. 4Shedding light on the catalytic activity of Histone Deacetylase 4 in the context of cardiac and metabolic phenotypes using a genetic approach2026
  5. 5The regulatory mechanisms and treatment of HDAC6 in immune dysregulation diseases2025 · 8 citations