Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 14, 2026International ImmunopharmacologyOpen Access

Macrophage HDAC3 drives obesity and adipose tissue metabolic maladaptation through GDF3-mediated inflammation and chromatin remodeling

View Full Paper
Ask AI
Bookmark
Share

Authors

YZYulin ZhangYCYe ChenJLJia Liu

Discussion

Loading...

Member takes

Overview

Preclinical study reveals macrophage HDAC3 drives adipose inflammation and metabolic dysfunction via GDF3, suggesting a target for obesity-related diabetes.

Key Points

  • To investigate the mechanism by which histone deacetylase 3 (HDAC3) in adipose tissue macrophages mediates metabolic stress, tissue inflammation, and obesity-linked type 2 diabetes.
  • Investigated the effects of macrophage-specific HDAC3 deficiency in diet-induced obese mouse models.
  • Evaluated epigenetic and chromatin alterations (H3K4Me3 and H3K27Ac modifications) linked to the growth differentiation factor 3 (GDF3) and HDAC3 axis.
  • Assessed human adipose tissue and macrophage samples for the co-expression of HDAC3 and GDF3 and correlated findings with clinical metabolic markers including BMI and blood glucose.
  • Macrophage-specific deficiency of HDAC3 decreased macrophage infiltration and tissue fibrosis, lowered weight gain and adiposity, and alleviated hyperglycemia in diet-induced obese mice.
  • HDAC3 suppressed inflammatory cytokine production via H3K4Me3/H3K27Ac-dependent chromatin remodeling, driven by the metabolic stress sensor GDF3.
  • Co-expression of HDAC3 and GDF3 was elevated in adipose tissue and macrophages of individuals with obesity, correlating positively with BMI, blood glucose, and proinflammatory gene levels.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3aa0926e14a848b2d2ehttps://doi.org/10.1016/j.intimp.2026.117385
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High-fat diet-induced adipose tissue-resident macrophages, T cells, and dendritic cells modulate chronic inflammation and adipogenesis during obesity2025 · 25 citations
  2. 2Adipocyte Gata3 Is a Diet-Inducible Driver of Pathological Adipose Remodeling and Systemic Metabolic Disease2026
  3. 3HDAC3 as an Immunometabolic Rheostat: Molecular Mechanisms of Deacylation Plasticity, Lactylation Dynamics, and Spatiotemporal Regulation2026
  4. 4HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM162018 · 26 citations
  5. 5Sex-Dependent Role of Adipose Tissue HDAC9 in Diet-Induced Obesity and Metabolic Dysfunction2022 · 13 citations