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July 5, 2026BMC Oral HealthOpen Access

Prognostic value of surgical margin and margin to depth of invasion ratio in oral squamous cell carcinoma: a meta-analysis

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Authors

JXJin XuYantai UniversityQCQian CuiUniversity of Electronic Science and Technology of ChinaYCYuehua ChenBGI Group (China)

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Implication

Meta-analysis compares surgical margin and depth of invasion ratio for predicting outcomes in oral squamous cell carcinoma, implying a need for improved evaluation standards.

Key Points

  • This study aims to compare the prognostic impact of surgical margin width and margin to depth of invasion ratio in oral squamous cell carcinoma.
  • Systematic search in PubMed, Web of Science, Embase, and Cochrane Library until April 1, 2026.
  • Meta-analysis conducted using STATA 18.0 software on 41 studies with 61,863 individuals.
  • Quality of included studies assessed with the Quality In Prognosis Studies (QUIPS) tool.
  • Poor surgical margin associated with overall survival (HR = 1.56, 95% CI 1.37–1.77, p < 0.001), disease-free survival (HR = 1.72, 95% CI 1.29–2.28, p < 0.001), and recurrence-free survival (HR = 1.99, 95% CI 1.53–2.58, p < 0.001).
  • Low margin to depth of invasion ratio linked to worse overall survival (HR = 1.36, 95% CI 1.21–1.54, p < 0.001) and disease-free survival (HR = 1.40, 95% CI 1.12–1.74, p = 0.003).
  • Variability in cutoff values, data sources, and geographical factors influences these associations.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a49f591f5d1d45b2880065ehttps://doi.org/10.1186/s12903-026-09103-x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recurrence of oral squamous cell carcinoma in surgically treated patients at Khartoum Teaching Dental Hospital retrospective cross-sectional study2024 · 12 citations
  2. 2Practical methods for incorporating summary time-to-event data into meta-analysis: updated guidance2025 · 60 citations
  3. 3Risk Factors of Microscopically Tumor-Free Surgical Margins for Recurrence and Survival of Oral Squamous Cell Carcinoma Patients2022 · 11 citations
  4. 4Margin to Depth of Invasion Ratio: A Significant Predictor of Survival in Patients With Oral Cancer2023 · 20 citations