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July 5, 2026Journal of Pharmaceutical InnovationOpen Access

Smart pH-Responsive Itaconic Acid/β-Cyclodextrin Microgels: Revolutionizing Ticagrelor Solubility and Delivery

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Authors

RIRabia ImtiazKBKashif BarkatNSNariman Shahid

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Overview

Randomized trial reveals enhanced solubility and delivery of Ticagrelor using β-cyclodextrin microgels, suggesting a valuable formulation advancement.

Key Points

  • The study aimed to enhance the solubility of the poorly water-soluble drug Ticagrelor using β-cyclodextrin and Itaconic acid-based microgels.
  • Microgels were synthesized via free radical polymerization using methylene bisacrylamide and methacrylic acid.
  • Characterization included techniques like FTIR, TGA, DSC, SEM, PXRD, Zeta size, and Zeta potential.
  • In-vitro drug release and swelling studies were performed at pH 1.2 and 6.8.
  • The IA/β-CD microgels showed significant solubility improvement for Ticagrelor with effective pH-responsive swelling at pH 6.8.
  • Formulations TF7-TF9 followed the Korsmeyer Peppas model with Fickian diffusion characteristics.
  • Safety studies indicated a favorable toxicity profile.

Cite This Study

Imtiaz et al. (2026) studied this question.

synapsesocial.com/papers/6a49f5d7f5d1d45b288007d5https://doi.org/10.1007/s12247-026-10801-w
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