PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
July 15, 2025Jurnal Sains Farmasi & Klinis

Advancing Ticagrelor Bioavailability: A Comprehensive Review of Solubility Enhancement Techniques

View Full Paper
Ask AI
Bookmark
Share

Authors

MSMuhammad Luthfi ShidikTSTania Miranda SarlieRMRachmat Mauludın

Discussion

Loading...

Member takes

Overview

Comprehensive review discusses how solubility enhancements improve bioavailability for ticagrelor, highlighting solid dispersion and co-crystals.

Key Points

  • Ticagrelor is a BCS class IV drug, facing challenges in solubility and permeability.
  • The bioavailability of ticagrelor after oral administration is about 36%, which is relatively low.
  • Several techniques, including solid dispersions and co-crystals, can enhance ticagrelor's solubility.
  • Understanding and improving ticagrelor's bioavailability can guide more effective formulations in future research.

Cite This Study

Shidik et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc7d5https://doi.org/10.25077/jsfk.12.1.50-62.2025
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preparation and in-vivo Evaluation of Ticagrelor Oral Liquid Self nano-emulsion2022 · 3 citations
  2. 2Strategic approach to developing a self-microemulsifying drug delivery system to enhance antiplatelet activity and bioavailability of ticagrelor2019 · 60 citations
  3. 3Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor2025 · 1 citations
  4. 4Formulation Development and Evaluation of Ticagrelor Oral Dispersible Tablets by Using Co-processed Superdisintegrants2024 · 1 citations
  5. 5Formulation, Optimization and Evaluation of Ticagrelor Liquisolid Tablets for Enhanced Solubility2024 · 1 citations