Why the study?
Ticagrelor is practically insoluble in water with an absolute bioavailability of about 36 percent, prompting efforts to improve its water solubility and bioavailability.
Population
In-vivo models (specific model not stated in abstract)
Design
Preclinical
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SNEDDS formulation improved ticagrelor release and exposure in animals; leaves open human translation and clinical adoption.
This study describes the formulation of a ticagrelor oral liquid self nano-emulsion aimed at improving the drug's water solubility and bioavailability.
A 2022 study studied this question.