Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 5, 2026MedicineOpen Access

Global burden and trends of appendicitis among adolescents and young adults: A systematic analysis for the Global Burden of Disease study 2021 and predictions to 2040.

View Full Paper
Ask AI
Bookmark
Share

Authors

QSQian SunMYMing YanHWHan Wang

Discussion

Loading...

Member takes

Overview

Systematic analysis reveals declining appendicitis rates in adolescents and young adults, suggesting effective interventions are needed.

Key Points

  • Assess the global prevalence and burden of appendicitis among adolescents and young adults from 1990 to 2021 and predict trends to 2040.
  • Analyzed data from the Global Burden of Disease database spanning 1990 to 2021.
  • Calculated point estimates, incidence rates, death rates, and DALY rates for ages 15 to 39 years.
  • Utilized the Bayesian age–period–cohort model for future projections.
  • Global appendicitis incidence among AYAs surpassed 10 million cases in 2021, with a decline from 391.46 to 368.43 cases per 100,000 population (EAPC −0.27, 95% CI: −0.34–−0.20).
  • Death rates declined with EAPC of −3.01 (95% CI: −3.23–−2.78) and DALY rates with EAPC of −2.59 (95% CI: −2.78–−2.40).
  • Projections indicate continued decrease in incidence and DALY rates from 2021 to 2040.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a49f68df5d1d45b28800dddhttps://doi.org/10.1097/md.0000000000049625
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global trends and inequalities in appendicitis burden among youth: Analysis of GBD 1990 to 20212026
  2. 2Trends in the global burden of appendicitis in children at global, regional, and national levels: An analysis using GBD 2021 data2026
  3. 3Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 20212024 · 85 citations
  4. 4Appendicitis burden in Africa, 2010–2023: temporal trends, pandemic-era deviations, and projections to 20302026
  5. 5The global, regional, and national burden of appendicitis in the elderly population aged 60 years and above from 1990 to 2021: trends, current status, and future predictions based on the 2021 global burden of disease data: a systematic analysis2025