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July 5, 2026Journal of the Egyptian Public Health AssociationOpen Access

Trends in the global burden of appendicitis in children at global, regional, and national levels: An analysis using GBD 2021 data

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Authors

JZJiansheng ZhouYFYulin FengKZKezhan Zhang

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Overview

Cross-sectional analysis shows rising appendicitis cases in children, highlighting disparities in healthcare resources globally.

Key Points

  • To analyze trends in the incidence, mortality, and disability burden of pediatric appendicitis using GBD 2021 data.
  • Cross-sectional analysis of Global Burden of Disease 2021 data
  • Age-standardized rates calculated for incidence, mortality, and disability-adjusted life years
  • Utilized linear regression and joinpoint analysis on 63,401,760 children from 1990 to 2021.
  • In 2021, global pediatric appendicitis cases were estimated at 2,193,019.79, a 24% increase from 1990.
  • Deaths declined by 68% to 2,319.37 over the same period, with significant decreases in ASMR and ASDR.
  • ASIR increased in the High-middle SDI region, while it decreased in the Low SDI region, indicating disparities in healthcare outcomes.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a49f60bf5d1d45b288009cfhttps://doi.org/10.1186/s42506-026-00229-y
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