Key result
Positive remodeling on pre-PCI MDCT linked to ~354% higher post-PCI cTnT elevation risk, alongside spotty calcification.
Why the study?
PCI is often complicated by post-procedural myocardial necrosis manifested by elevated cardiac biomarkers, prompting evaluation of the relation between MDCT culprit plaque characteristics and post-PCI cardiac troponin T elevation.
Observational (n=107)
Odds Ratio: 4.54 (95% CI 1.36–15.9)
p-value: p=0.014
May link plaque lipid content to post-PCI troponin rises in stable angina; leaves open whether imaging refines procedural risk assessment.
OBJECTIVES: The authors used multidetector computed tomography (MDCT) to study the relation between culprit plaque characteristics and cardiac troponin T (cTnT) elevation after percutaneous coronary intervention (PCI). BACKGROUND: Percutaneous coronary intervention is often complicated by post-procedural myocardial necrosis manifested by elevated cardiac biomarkers. METHODS: Stable angina patients (n = 107) with normal pre-PCI cTnT levels underwent 64-slice MDCT before PCI to evaluate plaque characteristics of culprit lesions. Patients were divided into 2 groups according to presence (group I, n = 36) or absence (group II, n = 71) of post-PCI cTnT elevation ≥3 times the upper limit of normal (0.010 ng/ml) at 24 h after PCI. RESULTS: Computed tomography attenuation values were significantly lower in group I than in group II (43.0 [26.5 to 75.7] HU vs. 94.0 [65.0 to 109.0] HU, p < 0.001). Remodeling index was significantly greater in group I than in group II (1.20 ± 0.18 vs. 1.04 ± 0.15, p < 0.001). Spotty calcification was observed significantly more frequently in group I than in group II (50% vs. 11%, p < 0.001). Multivariate analysis showed presence of positive remodeling (remodeling index >1.05; odds ratio: 4.54; 95% confidence interval: 1.36 to 15.9; p = 0.014) and spotty calcification (odds ratio: 4.27; 95% confidence interval: 1.30 to 14.8; p = 0.016) were statistically significant independent predictors for cTnT elevation. For prediction of cTnT elevation, the presence of all 3 variables (CT attenuation value <55 HU; remodeling index >1.05, and spotty calcification) showed a high positive predictive value of 94%, and their absence showed a high negative predictive value of 90%. CONCLUSIONS: MDCT may be useful in detecting which lesions are at high risk for myocardial necrosis after PCI.
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Watabe et al. (2012) conducted an observational in Stable Angina Pectoris (n=107). Positive remodeling and spotty calcification on MDCT vs. Absence of these plaque characteristics was evaluated on Post-PCI cTnT elevation ≥3 times the upper limit of normal (0.010 ng/ml) at 24 h after PCI (OR 4.54, 95% CI 1.36-15.9, p=0.014). Positive remodeling (OR 4.54; 95% CI 1.36-15.9) and spotty calcification on pre-PCI MDCT independently predicted post-PCI cardiac troponin T elevation in stable angina patients.
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