Key result
Invasively measured aortic pulse pressure was significantly associated with left ventricular mass index in subjects aged <50 years (β = 0.610, P=0.006), but not in those aged ≥50 years.
Why the study?
The impact of age on the association between central aortic hemodynamics and left ventricular remodeling has not been well elucidated.
Does age affect the association between invasively measured central blood pressure and left ventricular mass index in patients undergoing coronary angiography?
Observational (n=305)
Does age affect the association between invasively measured central blood pressure and left ventricular mass index in patients undergoing coronary angiography?
Aortic pulsatile hemodynamics are more strongly associated with left ventricular remodeling in younger patients (<50 years) compared to older patients.
Central hemodynamics may relate to LVMI differently by age in ICA patients; hypothesis-generating and should not yet alter practice.
Background: The impact of age on the association between central aortic hemodynamics and left ventricular (LV) remodeling has not been well elucidated. We compared the relationship between measurements of central blood pressure (CBP) and LV mass index (LVMI) according to their ages (<50 years versus ≥50 years). Methods: A total of 305 consecutive subjects (64.4 ± 10.9 years, 60.7% males) who underwent invasive coronary angiography (ICA) for the evaluation of coronary artery disease were prospectively enrolled. Just before ICA, CBP was measured at the aortic root using a pig-tail catheter, and CBP indices, including aortic systolic blood pressure (aSBP), aortic pulse pressure (aPP), aortic fractional pulse pressure (=aPP/mean aortic pressure), and aortic pulsatility index (=aPP/diastolic aortic pressure), were recorded. All subjects underwent transthoracic echocardiography, and LVMI was measured on the same day of ICA. Results: In simple linear correlation analyses, LVMI was associated with all CBP indices in subjects aged <50 years (n = 29) (P < .05 for each), but not in those aged ≥50 years (n = 276) (P > .05 for each). In the younger age group (≤50 years), multivariable analysis showed that aSBP (β = 0.457, P= .021) and aPP (β = 0.610, P= .006) had a significant association with LVMI after adjusting for possible confounding factors. The results remained consistent even when analyzed in a 1:1 propensity score-matched cohort. In conclusion, invasively measured aPP showed the closest association with LVMI in subjects aged <50 years, but not those aged ≥50 years. Conclusion: Aortic pulsatile hemodynamic status appears to have a greater effect on LV remodeling in younger people than in older people.
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Rhee et al. (2021) conducted an observational in Coronary artery disease (n=305). Central blood pressure indices (aSBP, aPP) vs. Older age group (≥50 years) was evaluated on Association between central blood pressure indices and left ventricular mass index (LVMI) (β = 0.610, p=0.006). Invasively measured aortic pulse pressure was significantly associated with left ventricular mass index in subjects aged <50 years (β = 0.610, P=0.006), but not in those aged ≥50 years.
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