Key result
Invasively measured central aortic systolic blood pressure and pulse pressure were independently associated with left ventricular end-diastolic pressure (aSBP β=0.345, P=0.001; aPP β=0.276, P=0.018).
Why the study?
Data on ventricular-arterial coupling using invasive hemodynamic studies are limited, prompting an evaluation of the interaction between aortic pressures and left ventricular end-diastolic pressure using invasive catheterization.
Do invasively measured central aortic pressures correlate with left ventricular end-diastolic pressure in stable patients undergoing coronary angiography?
Observational (n=104)
Do invasively measured central aortic pressures correlate with left ventricular end-diastolic pressure in stable patients undergoing coronary angiography?
Effect estimate: aSBP β = 0.345, aPP β = 0.276
p-value: p=0.001 and 0.018
Invasively measured central aortic systolic blood pressure and pulse pressure are independently associated with left ventricular end-diastolic pressure in stable patients undergoing coronary angiography, highlighting ventricular-arterial coupling.
OBJECTIVE: Data on ventricular-arterial coupling using invasive hemodynamic studies are limited. This study was performed to clarify the interaction between aortic pressures and left ventricular end-diastolic pressure (LVEDP) using invasive catheterization. PATIENTS AND METHODS: A total of 104 consecutive stable patients (mean age, 65.8 ± 10.0 years; 56% men) undergoing invasive coronary angiography (ICA) were prospectively evaluated. LVEDP and central aortic pressures [systolic blood pressure (aSBP) and diastolic blood pressure (aDBP)] were sequentially measured using a pigtail catheter before ICA. Aortic pulse pressure (aPP) was defined by the difference between aSBP and aDBP. RESULTS: A total of 82 patients (79%) had obstructive coronary artery disease (≥50% stenosis). The mean LVEDP value was 18.7 ± 6.4 mmHg. Univariable analyses showed that aSBP (r = 0.309, P = 0.001) and aPP (r = 0.286, P = 0.003) significantly correlated with LVEDP, whereas aDBP was not correlated with LVEDP (P > 0.05). Multivariable analysis revealed that aSBP (β = 0.345, P = 0.001) and aPP (β = 0.276, P = 0.018) remained independent predictors of LVEDP even after controlling for potential confounders. CONCLUSION: Invasively measured aSBP and aPP were independently associated with invasively measured LVEDP in patients undergoing ICA. This result provides additional evidence of a close interaction between central aortic pressure and LV diastolic function in this population.
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Kim et al. (2019) conducted an observational in Stable patients undergoing invasive coronary angiography (n=104). Invasive measurement of central aortic pressures and LVEDP was evaluated on Correlation between central aortic pressures and LVEDP (aSBP β = 0.345, aPP β = 0.276, p=0.001 and 0.018). Invasively measured central aortic systolic blood pressure and pulse pressure were independently associated with left ventricular end-diastolic pressure (aSBP β=0.345, P=0.001; aPP β=0.276, P=0.018).
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