Key result
Isolated central hypertension had a 3.71-fold greater risk of masked hypertension (95% CI 1.48-9.32), and isolated brachial hypertension had a 4.65-fold greater risk of white coat hypertension.
Why the study?
Disagreements in office brachial and central BP have identified novel hypertension phenotypes (ICH and IBH), but their relationship with ambulatory BP phenotypes was unknown.
Does the presence of isolated central or brachial hypertension predict discordant ambulatory blood pressure phenotypes in individuals undergoing 24-hour BP monitoring?
Cross-Sectional (n=753)
Does the presence of isolated central or brachial hypertension predict discordant ambulatory blood pressure phenotypes in individuals undergoing 24-hour BP monitoring?
Relative Risk: 3.71 (95% CI 1.48–9.32)
p-value: p=0.005
Identifying isolated central or brachial hypertension in the office can help detect patients at higher risk for masked or white-coat hypertension on 24-hour ambulatory monitoring.
These phenotypes may refine ambulatory BP interpretation; leaves open their prognostic value and therapeutic implications.
Disagreements in office brachial and central blood pressure (BP) have resulted in the identification of novel hypertension phenotypes, namely isolated central hypertension (ICH) and isolated brachial hypertension (IBH). This study investigated the relationship of ICH and IBH with ambulatory BP phenotypes among 753 individuals (mean age = 47.6 ± 15.2 years, 48% males) who underwent office and 24-hours brachial and central BP measures using a Mobil-O-Graph PWA monitor. Thresholds for elevated office central and brachial BP were 130/90 and 140/90 mm Hg. Results of multivariable analysis adjusted for potential confounders showed that ICH (n = 25) had 3.71-fold (95% CI 1.48-9.32; P = .005) greater risk of masked hypertension than normal brachial/central BP (n = 362), while IBH (n = 20) had 4.65-fold (95% CI 1.76-12.25; P = .002) greater risk of white coat hypertension compared with combined brachial/central hypertension (n = 346). These findings suggest that the diagnosis of ICH and IBH might be useful in identifying individuals at higher risk of presenting discordant office and ambulatory BP phenotypes.
No takes yet. Share an insight, caveat, or question.
Feitosa et al. (2020) conducted a cross-sectional in Hypertension phenotypes (n=753). Isolated central hypertension (ICH) and isolated brachial hypertension (IBH) vs. Normal brachial/central BP and combined brachial/central hypertension was evaluated on Masked hypertension (RR 3.71, 95% CI 1.48-9.32, p=0.005). Isolated central hypertension had a 3.71-fold greater risk of masked hypertension (95% CI 1.48-9.32), and isolated brachial hypertension had a 4.65-fold greater risk of white coat hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: