Key result
In patients with primary synovial sarcoma of the digestive system, large tumor size ≥5 cm and increasing age were associated with a higher risk of mortality.
Why the study?
Synovial sarcoma is a rare malignant neoplasm that infrequently affects the digestive system, with fewer than 70 cases reported.
Case Report (n=68)
This case report highlights a rare presentation of primary monophasic synovial sarcoma in the rectum, confirmed by molecular testing.
Answers are grounded in this paper and cite their sources.
Rare rectal monophasic synovial sarcoma confirmed by IHC and SYT/SSX testing; leaves open optimal diagnostic algorithms for GI spindle cell tumors.
Synovial sarcoma is a rare malignant mesenchymal neoplasm that often occurs in the extremities. Less than 70 cases of primary synovial sarcoma occurring in the digestive system have been reported. We present a case of a 48-year-old woman with a spindle cell tumor in the rectum that stained positive for AE1/3 (focal), vimentin, CD99, BCL2, EMA (focal), and MiB-1 (15%). Ultimately, the lesion was diagnosed as a primary rectal monophasic synovial sarcoma and confirmed by molecular testing for SYT/SSX1 gene fusion. Analysis of previous publications indicated that patients of advanced age or a large tumor size (≥5 cm) have a higher risk of progressing rapidly to death after diagnosis of synovial sarcoma in the digestive system.
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Zhang et al. (2021) conducted a case report in Primary synovial sarcoma of the digestive system (n=68). Large tumor size (≥5 cm) vs. Tumor size <5 cm was evaluated on Mortality (HR 1.46, p=0.003). In patients with primary synovial sarcoma of the digestive system, large tumor size ≥5 cm and increasing age were associated with a higher risk of mortality.
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