Key result
Prehypertension was associated with significantly higher aortic pulse wave velocity (10 vs. 8.6 m/s; p=0.004) and augmentation index (21% vs. 10%; p=0.0001) compared to normotensive controls.
Why the study?
Does prehypertension increase arterial stiffness and wave reflections compared to normotension?
Population
85 subjects, comprising 45 subjects with prehypertension and an age-matched control group of 40 normotensive…
Comparison
Prehypertension (observational exposure) vs Normotension (age-matched control group)
Design
Case-control
Authors
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May identify early vascular changes in prehypertension; leaves open prognostic value and need for outcome trials.
Observational (n=85)
Does prehypertension increase arterial stiffness and wave reflections compared to normotension?
Absolute Event Rate: 10% vs 8.6%
p-value: p=0.004
Arterial stiffness and wave reflections are significantly increased even at the prehypertensive stage, suggesting early vascular impairment before the onset of clinical hypertension.
Gedikli et al. (2010) conducted an observational in Prehypertension (n=85). Prehypertension vs. Normotensive controls was evaluated on Aortic pulse wave velocity (PWV) (p=0.004). Prehypertension was associated with significantly higher aortic pulse wave velocity (10 vs. 8.6 m/s; p=0.004) and augmentation index (21% vs. 10%; p=0.0001) compared to normotensive controls.
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