Can the high-precision ultrasound—Sonographic system be a predictable diagnostic tool for diagnosing parkinson`s cross-sectional area (CSA) of vagal nerve

Gut-brain-axis(GBA) is critical in Parkinson disease(PD) progression for which cross-sectional area(CSA) of vagus-nerve/or vagal-nerve (VN, i.e., cranial-nerve X) can be used in the diagnosis of PD. GBA is a bidirectional interaction amid central plus enteric-nervous-system(ENS), connecting sensitive/emotional and cognitive centers of brain via peripheral intestinal functions. GBA interacts with enteric microbiota, central plus enteric nervous systems. We hypothesize that the CSA of VN is reduced in PD patients when linked to healthy population group (control participants). : The CSA of the VN is measured bidirectionally in >30 Parkinson subjects,>50 healthy controls at the level of common carotid-artery applying higher-dynamic-range ultrasound system (better pixel-resolutions) for high-precision ultrasonography (ultrasonography), confidence of real-time imaging also instant insights with ultrasound solutions. : Mean CSA of left VN in PD and control cohort was 2.10, 1.90, in right 2.54,2.24mm yet no variation within CSA of VN in Parkinson`s when compared to health-population(p≤0.079). The mean CSA of right VN was significantly >left (p< 0.001). Variables like age, sex and autonomic symptoms were no significant predictors of CSA of VN. : The CSA of VN with ultrasonograph system is inconsistent/ or unpredictable diagnostic tool in PD diagnosis.