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July 6, 2026Analytical and Bioanalytical ChemistryOpen Access

A robust and validated method for the determination of 21 urinary metabolites of 15 plasticizers, including phthalates, DEHTP, and DINCH, by online SPE and liquid chromatography-tandem mass spectrometry

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Authors

RMRosa MercadanteSCSimone CafagnaMRMarco Rizzo

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Overview

Randomized trial quantifies urinary metabolites of plasticizers in the general population, suggesting effective biomonitoring.

Key Points

  • To develop a method for quantifying urinary metabolites of plasticizers as biomarkers for human exposure.
  • Analyzed 21 urinary metabolites from 15 plasticizers using liquid chromatography-triple quadrupole mass spectrometry (LC-MS/MS).
  • Samples underwent enzymatic hydrolysis and solid phase extraction (SPE).
  • Validation performed per international guidelines with proficiency testing on urine samples.
  • Assay showed high accuracy (relative standard deviation within 15.6%) and sensitivity (LLOQ 0.10 to 0.78 µg/L).
  • Most abundant metabolites identified include monoethyl phthalate (38 µg/L) and mono(2-ethyl-5-carboxypentyl) terephthalate (11 µg/L).
  • Method demonstrates suitability for large-scale biomonitoring studies, with successful validation and recovery rates between 84-111%.

Cite This Study

Mercadante et al. (2026) studied this question.

synapsesocial.com/papers/6a4b453d997070ff83b5b079https://doi.org/10.1007/s00216-026-06634-8
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