What does this research mean for the field?

Secondary metabolites of plasticizers exhibit fair-to-good temporal stability in urine, and toxicokinetic modeling of intermittent exposure provides more realistic daily intake estimates than traditional mass-balance approaches. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the temporal variability of plasticizer metabolites in consecutively collected urine samples and estimate exposure levels using toxicokinetic reverse dosimetry modeling.

August 23, 2026Journal of Exposure Science & Environmental EpidemiologyOpen Access

Biomonitoring-based exposure assessment of phthalate and non-phthalate plasticizers: methodological insights from a 7-day consecutive sampling case study in Korea

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Authors

JKJinhyun Kwon JHJin-Yeong Heo ALAram Lee

Discussion

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Overview

Consecutive sampling study reveals temporal variability and dietary exposure routes of alternative plasticizers in adults, highlighting toxicokinetics for accurate exposure estimation.

Key Points

To evaluate the temporal variability of plasticizer metabolites in consecutively collected urine samples and estimate exposure levels using toxicokinetic reverse dosimetry modeling.
Quantified 20 metabolites of six plasticizer compounds (DiNP, DiDP, DEHA, DEHTP, DINCH, and TOTM) across 218 urine samples collected over 7 consecutive days from 6 adults in Korea.
Calculated intraclass correlation coefficients (ICCs) and Spearman correlations between first morning voids and daily average concentrations to evaluate biomarker temporal reproducibility.
Combined time-activity diaries with toxicokinetic models to reconstruct daily intake levels under intermittent versus continuous ingestion scenarios.
Metabolites of DiNP, DEHA, and DEHTP were detected in >70% of samples, with first morning voids correlating moderately with daily averages (Spearman's ρ = 0.34–0.62, p ≤ 0.05).
Overall ICCs ranged from 0.16 to 0.73, with carboxylated metabolites demonstrating fair-to-good reproducibility for DiNP, DEHA, and DINCH (ICC = 0.57–0.68) and the hydroxylated metabolite showing highest stability for DEHTP (ICC = 0.62).
Processed food intake was identified as the primary exposure route, with toxicokinetic modeling under intermittent ingestion yielding lower and more realistic intake estimates than continuous exposure assumptions.

Cite This Study

Kwon et al. (2026) studied this question.

synapsesocial.com/papers/6a8aade47677a3411444657a https://doi.org/10.1038/s41370-026-00963-7

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August 23, 2026Journal of Exposure Science & Environmental EpidemiologyOpen Access

Biomonitoring-based exposure assessment of phthalate and non-phthalate plasticizers: methodological insights from a 7-day consecutive sampling case study in Korea

View Full Paper

Ask AI

Bookmark

Authors

JKJinhyun Kwon JHJin-Yeong Heo ALAram Lee

Discussion

Member takes

Overview

Consecutive sampling study reveals temporal variability and dietary exposure routes of alternative plasticizers in adults, highlighting toxicokinetics for accurate exposure estimation.

Key Points

To evaluate the temporal variability of plasticizer metabolites in consecutively collected urine samples and estimate exposure levels using toxicokinetic reverse dosimetry modeling.
Quantified 20 metabolites of six plasticizer compounds (DiNP, DiDP, DEHA, DEHTP, DINCH, and TOTM) across 218 urine samples collected over 7 consecutive days from 6 adults in Korea.
Calculated intraclass correlation coefficients (ICCs) and Spearman correlations between first morning voids and daily average concentrations to evaluate biomarker temporal reproducibility.
Combined time-activity diaries with toxicokinetic models to reconstruct daily intake levels under intermittent versus continuous ingestion scenarios.
Metabolites of DiNP, DEHA, and DEHTP were detected in >70% of samples, with first morning voids correlating moderately with daily averages (Spearman's ρ = 0.34–0.62, p ≤ 0.05).
Overall ICCs ranged from 0.16 to 0.73, with carboxylated metabolites demonstrating fair-to-good reproducibility for DiNP, DEHA, and DINCH (ICC = 0.57–0.68) and the hydroxylated metabolite showing highest stability for DEHTP (ICC = 0.62).
Processed food intake was identified as the primary exposure route, with toxicokinetic modeling under intermittent ingestion yielding lower and more realistic intake estimates than continuous exposure assumptions.

Cite This Study

Kwon et al. (2026) studied this question.

synapsesocial.com/papers/6a8aade47677a3411444657a https://doi.org/10.1038/s41370-026-00963-7

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