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July 6, 2026Journal of Translational MedicineOpen Access

The lncRNA-m6A axis in cancer: a bidirectional regulatory network in tumor progression and therapeutic resistance

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Authors

ZWZiqiang WangAcademy of Medical SciencesTLTianzi LiBaoji University of Arts and SciencesKLKun LiShandong Provincial QianFoShan Hospital

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Implication

This review demonstrates the interplay of lncRNA and m6A methylation in tumor progression and resistance mechanisms, suggesting new therapeutic strategies.

Key Points

  • The aim is to elucidate the roles of lncRNA and m6A methylation in cancer progression and therapeutic resistance.
  • Synthesis of current knowledge on lncRNA and m6A in cancer
  • Discussion of experimental strategies like CRISPR-based editing and site-directed mutagenesis
  • Evaluation of methodological limitations in m6A detection
  • m6A modification affects lncRNA stability and function through distinct reader proteins.
  • lncRNAs modulate the activity of m6A machinery to establish feedback loops affecting cancer hallmarks.
  • m6A-related lncRNA signatures serve as potential prognostic biomarkers for cancer monitoring.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a4b453d997070ff83b5b0c8https://doi.org/10.1186/s12967-026-08561-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The collaborative epitranscriptome: bidirectional crosstalk between m6A methylation and noncoding RNAs in cancer pathogenesis and precision therapy2026
  2. 2M6A RNA modification: focusing on non-small cell lung cancer progression, therapeutic strategies and challenges2025 · 3 citations
  3. 3Overview of the interplay between m6A methylation modification and non-coding RNA and their impact on tumor cells2024 · 6 citations
  4. 4m6A RNA Modification: Technologies Behind Future Anti-Cancer Therapy2025 · 3 citations
  5. 5N6-methyladenine modification in noncoding RNAs and its function in cancer2020 · 57 citations